Thermoreversible Biogels for Intranasal Delivery of Rizatriptan Benzoate

The objective of the present study was to formulate and evaluate a thermoreversible formulation containing rizatriptan benzoate for intranasal administration. Chitosan and aqueous β−glycerolphosphate were mixed in cold condition to obtain chitosan-β−glycerolphosphate mixtures, which served as the thermoreversible systems. Rizatriptan benzoate was incorporated at a fi nal strength of 25 mg/ml. Both in vitro release and ex vivo permeation of rizatriptan from gels were measured at 37o using Franz diffusion cells Formulations were tested in vivo in mice for reduction in locomotor activity using digital actophotometer and nasal mucosal tissues were examined histopathologically.